Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic).
نویسندگان
چکیده
We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.
منابع مشابه
Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy.
Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
متن کاملAsymmetric epoxidation of olefins catalyzed by Ti(salan) complexes using aqueous hydrogen peroxide as the oxidant*
Ti(salan) complexes were found to be efficient catalysts for asymmetric epoxidation with aqueous hydrogen peroxide as the oxidant. In the presence of pH 7.4 phosphate buffer, the reaction of various conjugate olefins proceeded smoothly to afford the corresponding epoxides in high yield with high enantioselectivity, even on a multigram scale. Ti(salan) complexes could be prepared from Ti(OiPr)4 ...
متن کاملA Comparison between the Effect of Cr and W Addition on Formation Kinetic of Nanostructure TiAl(γ) Alloy by Mechanical Alloying Route
In this research, mechanical alloying was used to produce Ti-50Al, Ti-45Al-5Cr and Ti-45Al-5W (at%) alloys. The effect of ternary addition (Cr and W) on microstructure and production efficiency of TiAl alloy were investigated. Alloying was performed in a planetary mill and the milling time varying from 5 to 70h. The structural evaluation in these powders was done by X-ray diffraction (XRD) tech...
متن کاملEvaluation of the tantalum-titanium phase diagram from ab-initio calculations
The thermodynamic properties of the Ta-Ti binary system below 900 C are not well known. In particular, the location and shape of the solvus between the phase separation region at low temperatures and the solid solution at high temperatures are not well defined. In this study, we present a thermodynamic description for this system based on ab-initio calculations. The formation enthalpies of bcc ...
متن کاملTitanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice
The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of medicinal chemistry
دوره 58 18 شماره
صفحات -
تاریخ انتشار 2015